Publication list

Ramakrishnan, K., Johnson, R. L., Winter, S. D., Worthy, H. L., Thomas, C., Humer, D. C., Spadiut, O., Hindson, S. H., Wells, S., Barratt, A. H., Menzies, G. E., Pudney, C. R., & Jones, D. D. (2023). Glycosylation increases active site rigidity leading to improved enzyme stability and turnover. The FEBS Journal.

Powell, L. C., Cullen, J. K., Boyle, G. M., De Ridder, T., Yap, P.-Y., Xue, W., Pierce, C. J., Pritchard, M. F., Menzies, G. E., & Abdulkarim, M. (2022). Topical, immunomodulatory epoxy-tiglianes induce biofilm disruption and healing in acute and chronic skin wounds. Science Translational Medicine, 14(662), eabn3758.

McAllister, B., Donaldson, J., Binda, C., Powell, S., Chughtai, U., Edwards, G., Stone, J., Lobanov, S., Elliston, L., Schuhmacher, L., Rees, E., Menzies, G., Ciosi, M., Maxwell, A., Chao, M., Eun Pyo, H., Lucente, D., Wheeler, V., Jong-Min, L., . . . Massey, T. (2022). Exome sequencing of individuals with Huntington’s disease implicates FAN1 nuclease activity in slowing CAG expansion and disease onset. Nature Neuroscience, 25, 446-457. https://doi.org/10.1038/s41593-022-01033-5

Bracher-Smith, M., Rees, E., Menzies, G., Walters, J., O'Donovan, M., Owen, M. J., Kirov, G., & Escott-Price, V. (2022). Machine learning for prediction of schizophrenia using genetic and demographic factors in the UK Biobank. Schizophrenia research, 246, 156-164. https://doi.org/10.1016/j.schres.2022.06.006

Menzies, G. E., & Torvell, M. (2021). Exciting new tools for studying TREM2 in dementia. Structure,29(11), 1215-1216.

Menzies, G., Prior, I. A., Brancale, A., Reed, S. H., & Lewis, P. D. (2021). Carcinogen-induced DNA structural distortion differences in the RAS gene isoforms; the importance of local sequence. BMC Chemistry, 15. https://doi.org/10.1186/s13065-021-00777-8

Maguire, E., Menzies, G. E., Phillips, T., Sasner, M., Williams, H. M., Czubala, M. A., Evans, N., Cope, E. L., Sims, R., & Howell, G. R. (2021). PIP2 depletion and altered endocytosis caused by expression of Alzheimer's disease‐protective variant PLCγ2 R522. The EMBO Journal,40(17), e105603.

Dennison, C. A., Legge, S. E., Bracher-Smith, M., Menzies, G., Escott-Price, V., Smith, D. J., Doherty, A. R., Owen, M. J., O'Donovan, M. C., & Walters, J. T. R. (2021). Association of genetic liability for psychiatric disorders with accelerometer-assessed physical activity in the UK Biobank. PLoS One, 16(3). https://doi.org/10.1371/journal.pone.0249189

de Rojas, I., Moreno-Grau, S., Tesi, N., Grenier-Boley, B., Andrade, V., Jansen, I. E., Pedersen, N. L., Stringa, N., Zettergren, A., Hernández, I., Montrreal, L., Antúnez, C., Antonell, A., Tankard, R. M., Bis, J. C., Sims, R., Bellenguez, C., Quintela, I., González-Perez, A., . . . Ruiz, A. (2021). Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nature Communications, 12(1). https://doi.org/10.1038/s41467-021-22491-8

Zelek, W. M., Menzies, G. E., Brancale, A., Stockinger, B., & Morgan, B. P. (2020). Characterizing the original anti‐C5 function‐blocking antibody, BB5. 1, for species specificity, mode of action and interactions with C5. Immunology, 161(2), 103-113.

Grama, S., Willcocks, I., Hubert, J., Pardiñas, A., Legge, S., Bracher-Smith, M., Menzies, G., Hall, L., Pocklington, A., Anney, R., Bray, N., Escott-Price, V., & Caseras, X. (2020). Polygenic risk for schizophrenia and subcortical brain anatomy in the UK Biobank cohort. Translational psychiatry, 10. https://doi.org/10.1038/s41398-020-00940-0

Bellou, E., Baker, E., Leonenko, G., Bracher-Smith, M., Daunt, P., Menzies, G., Williams, J., & Escott-Price, V. (2020). Age-dependent effect of APOE and polygenic component on Alzheimer's disease. Neurobiology of Aging, 93, 69-77. https://doi.org/10.1016/j.neurobiolaging.2020.04.024

Menzies, G. E., Sims, R., & Williams, J. (2019). Molecular Dynamics simulations of TREM2 variants R47H and R62H show structural alterations at key binding regions leading to possible implications for mechanisms in Alzheimer’s disease.

Legge, S. E., Jones, H. J., Kendall, K. M., Pardiñas, A. F., Menzies, G., Bracher-Smith, M., Escott-Price, V., Rees, E., Davis, K. A., & Hotopf, M. (2019). Association of genetic liability to psychotic experiences with neuropsychotic disorders and traits. JAMA Psychiatry, 76(12), 1256-1265.

Kunkle, B. W., Grenier-Boley, B., Sims, R., Bis, J. C., Damotte, V., Naj, A. C., Boland, A., Vronskaya, M., van der Lee, S. J., Amlie-Wolf, A., Bellenguez, C., Frizatti, A., Chouraki, V., Martin, E. R., Sleegers, K., Badarinarayan, N., Jakobsdottir, J., Hamilton-Nelson, K. L., Moreno-Grau, S., . . . Consort, E. R. f. A. s. D. (2019). Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics, 51(3), 414-430. https://doi.org/10.1038/s41588-019-0358-2

Grozeva, D., Saad, S., Menzies, G. E., & Sims, R. (2019). Benefits and challenges of rare genetic variation in Alzheimer's disease. Current Genetic Medicine Reports, 7(1), 53-62. https://doi.org/10.1007/s40142-019-0161-5

Escott-Price, V., Bracher-Smith, M., Menzies, G., Walters, J., Kirov, G., Owen, M. J., & O'Donovan, M. C. (2019). Genetic liability to schizophrenia is negatively associated with educational attainment in UK Biobank. Journal of Molecular Psychiatry, -. https://doi.org/10.1038/s41380-018-0328-6

Powell, L. C., Pritchard, M. F., Ferguson, E. L., Powell, K. A., Patel, S. U., Rye, P. D., Sakellakou, S.-M., Buurma, N. J., Brilliant, C. D., Copping, J. M., Menzies, G. E., Lewis, P. D., Hill, K. E., & Thomas, D. W. (2018). Targeted disruption of the extracellular polymeric network of pseudomonas aeruginosa biofilms by alginate oligosaccharides. npj Biofilms and Microbiomes, 4. https://doi.org/10.1038/s41522-018-0056-3

Bryant, A. H., Menzies, G. E., Scott, L. M., Spencer-Harty, S., Davies, L. B., Smith, R. A., Jones, R. H., & Thornton, C. A. (2017). Human gestation-associated tissues express functional cytosolic nucleic acid sensing pattern recognition receptors. Clinical and Experimental Immunology, 189(1), 36-46. https://doi.org/10.1111/cei.12960

Pritchard, M. F., Powell, L. C., Menzies, G. E., Lewis, P. D., Hawkins, K., Wright, C., Doull, I., Walsh, T. R., Onsoyen, E., Dessen, A., Myrvold, R., Rye, P. D., Myrset, A. H., Stevens, H. N. E., Hodges, L. A., MacGregor, G., Neilly, J. B., Hill, K. E., & Thomas, D. W. (2016). A new class of safe oligosaccharide polymer therapy to modify the mucus barrier of chronic respiratory disease. Molecular Pharmaceutics, 13(3), 863-872. https://doi.org/10.1021/acs.molpharmaceut.5b00794

Avancini, D., Menzies, G., Morgan, C., Wills, J., Johnson, G. E., White, P. A., & Lewis, P. D. (2016). MutAIT: an online genetic toxicology data portal and analysis tools. Mutagenesis, 31(3), 323-328. https://doi.org/10.1093/mutage/gev050

Menzies, G., Reed, S. H., Brancale, A., & Lewis, P. D. (2015). Base damage, local sequence context and TP53 mutation hotspots: a molecular dynamics study of benzo[a]pyrene induced DNA distortion and mutability. Nucleic Acids Research, 43(19), 9133-9146. https://doi.org/10.1093/nar/gkv910

Lewis, P. D., & Menzies, G. (2015). Vibrational spectra, principal components analysis and the horseshoe effect. Vibrational Spectroscopy, 81, 62-67. https://doi.org/10.1016/j.vibspec.2015.10.002

Menzies, G., Fox, H. R., Marnane, C., Pope, L., Prabhu, V., Winter, S., Derrick, A. V., & Lewis, P. D. (2014). Fourier transform infrared for noninvasive optical diagnosis of oral, oropharyngeal, and laryngeal cancer. Translational Research, 163(1), 19-26. https://doi.org/10.1016/j.trsl.2013.09.006